Lisa Cosgrove

Global Burden Disease Estimates for Major Depressive Disorders (MDD): A review of diagnostic instruments used in studies of prevalence

Cosgrove L, Brhlikova P, Lyus R, Herrawi F, D’Ambrozio G, Abi-Jaoude E, Pollock AM, Community Mental Health Journal. 2024 doi: 10.1007/s10597-024-01302-6

Abstract:

Global Burden of Disease (GBD) estimates have significant policy implications nationally and internationally. Disease burden metrics, particularly for depression, have played a critical role in raising governmental awareness of mental health and in calculating the economic cost of depression. Recently, the World Health Organization ranked depression as the single largest contributor to global disability. The main aim of this paper was to assess the basis upon which GBD prevalence estimates for major depressive disorder (MDD) were made. We identify the instruments used in the 2019 GBD estimates and provide a descriptive assessment of the five most frequently used instruments. The majority of country studies, 356/566 (62.9%), used general mental health screeners or structured/semi-structured interview guides, 98/566 (17.3%) of the studies used dedicated depression screeners, and 112 (19.8%) used other tools for assessing depression. Thus, most of the studies used instruments that were not designed to make a diagnosis of depression or assess depression severity. Our results are congruent with and extend previous research that has identified critical flaws in the data underpinning the GBD estimates for MDD. Despite the widespread promotion of these prevalence estimates, caution is needed before using them to inform public policy and mental health interventions. This is particularly important in lower-income countries where resources are scarce. Read more …


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“Reducing the Treatment Gap” Poses Human Rights Risks

(2024)

Lisa Cosgrove, Cristian Montenegro, Lee Edson Yarcia, Gianna D’Ambrozio and Julie Hannah, Health and Human Rights Journal, June 2024, Vol 26, Number 1

Abstract:
The United Nations (UN) officially acknowledged the “global burden” of mental disorders in September 2015, when mental health was included in the UN Sustainable Development Goals (SDGs). In so doing, the UN identified mental health as a priority for global development. The call to “close the treatment gap” was seen as a way to both uphold the right to treatment and integrate mental health into the SDGs, with many asserting that this is a human rights-based approach to transforming mental health. Although using the SDG framework is a sensible and necessary approach to catalyze action on mental health, the integration of mental health into the SDGs has sparked debates about the relevance and role of human rights frameworks in this area. For example, the latest draft resolution on mental health and sustainable development, presented by Mexico to the UN General Assembly, has been met with renewed calls to avoid the psychiatrization of the SDGs. Psychiatrization, in this context, points to the process by which “psychiatric institutions, knowledge, and practices affect an increasing number of people, shape more and more areas of life, and further psychiatry’s importance in society as a whole.” Concerns about psychiatrization stem from the fact that the focus is predominantly on scaling up the diagnosis and treatment of mental disorders, without paying attention to how a biomedical approach is limited in addressing the environmental, social, economic, and political determinants of mental health. Further, the emphasis on “closing the treatment gap” selectively deploys human rights in order to promote increased access to Western biomedical treatments. In so doing, there is a risk that the foundational principles of interdependence and indivisibility of international human rights will not be brought to fruition. What is needed is a holistic, rights-based approach that focuses not only on the clinical or individual interventions and outcomes but also on the process and contexts of implementation. That is why it is critical to ask “what type of evidence is valued (and devalued).” Thus, any discussions about the meaning and logistics of including global mental health as a priority for global development must include the voices of those most affected. Read more

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Industry Influence on Mental Health Research: Depression as a Case Example

Cosgrove L, Patterson EH, Bursztajn HJ, Front Med (Lausanne). 2024 Jan 23;10:1320304 DOI: 10.3389/fmed.2023.1320304

Abstract:

Emotional distress has been rising since before the COVID-19 pandemic and the public is told that depression is a major public health problem. For example, in 2017 depressive disorders were ranked as the third leading cause of “years lost to disability” and the World Health Organization now ranks depression as the single largest contributor to global disability. Although critical appraisals of the epidemiological data raise questions about the accuracy of population-based depression estimates, the dominance of the medical model and the marketing of psychotropics as “magic bullets,” have contributed to a dramatic rise in the prescription of psychiatric drugs. Unfortunately, the pharmaceutical industry’s influence on psychiatric research and practice has resulted in over-estimates of the effectiveness of psychotropic medications and an under-reporting of harms. This is because the principles that govern commercial entities are incongruent with the principles that guide public health research and interventions. In order to conduct mental health research and develop interventions that are in the public’s best interest, we need non-reductionist epistemological and empirical approaches that incorporate a biopsychosocial perspective. Taking depression as a case example, we argue that the socio-political factors associated with emotional distress must be identified and addressed. We describe the harms of industry influence on mental health research and show how the emphasis on “scaling up” the diagnosis and treatment of depression is an insufficient response from a public health perspective. Solutions for reform are offered. Read more


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Conflicts of Interest Should be Prohibited Among the Diagnostic and Statistical Manual of Mental Disorders Panel and Task Force Members

L Cosgrove, BMJ 2024;384:q36

Abstract:
When the DSM-5 text revision was published in 2022, we identified the amount and type of payments received by DSM panel members—a task made possible by the development of the Open Payments database. We hoped that there would be a decrease in financial conflicts of interest. As with DSM-IV and DSM-5, however, conflicts of interest among the panel members for the DSM-5 text revision were prevalent. Of the 92 panel members who met inclusion criteria, 55 (60%) received payments from industry. Collectively, these panel members received $14.2m. Read more

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Undisclosed Financial Conflicts of Interest in DSM-5-TR: cross sectional analysis

Davis L C, Diianni A T, Drumheller S R, Elansary N N, DAmbrozio G N, Herrawi F, Piper,J, Cosgrove, L
BMJ 2024; 384 :e076902 doi:10.1136/bmj-2023-076902

Abstract:

Conflicts of interest among panel members of DSM-5-TR were prevalent. Because of the enormous influence of diagnostic and treatment guidelines, the standards for participation on a guideline development panel should be high. A rebuttable presumption should exist for the Diagnostic and Statistical Manual of Mental Disorders to prohibit conflicts of interest among its panel and task force members. When no independent individuals with the requisite expertise are available, individuals with associations to industry could consult to the panels, but they should not have decision making authority on revisions or the inclusion of new disorders. Read more …


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Global Burden of Disease 2017 Estimates for Major Depressive Disorder: A critical appraisal of the epidemiological evidence

Lyus R, Buamah C, Pollock AM, Cosgrove L, Brhlikova P. Journal of the Royal Society of Medicine Open. 2023;14(9). doi:10.1177/20542704231197594

Abstract:

.This study aims to critically appraise the quality of the epidemiological studies underpinning the GBD 2017 estimates for MDD with respect to i) the four GBD 2017 inclusion criteria and ii) the population coverage of the studies by country and WHO region. The WHO’s ranking of depression as the single largest contributor to global disability (20) is being used to advocate for scaling up depression treatment, particularly in the global south where resources are limited. However, GBD 2017 estimates are based on incomplete country and population coverage and unclear methodologies. Extrapolation of single study estimates, the inclusion of studies with non-representative populations, and lack of specific data on MDD, undermines the reliability of many country and regional estimates. The critical flaws in the data underpinning the GBD 2017 estimates mean that policymakers should interpret these with caution. Read more …


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Becoming a Phronimos: Evidence-Based Medicine, Clinical Decision Making, and the Role of Practical Wisdom in Primary Care

Cosgrove, L. & Shaughnessy, A. (2023), Journal of the American Board of Family Medicine. doi: 10.3122/jabfm.2023.230034R1

Abstract:

There has been much discussion about the overmedicalization of human experience and the problems incurred by overzealous action-oriented medical care. In this paper we describe the Aristotelean virtue of phronesis, or practical wisdom, and discuss how it can be developed by interested clinicians. We argue that becoming a phronimos requires conscious attention to one’s practice by using feedback to continually improve. But there must also be judicious adherence to clinical practice guidelines and advocacy for people-as-patients at individual, community, and national levels. Read more …


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Why Psychiatry Needs an Honest Dose of Gentle Medicine

Cosgrove L, D’Ambrozio G, Herrawi F, Freeman M and Shaughnessy A (2023), Front. Psychiatry 14:1167910. doi:10.3389/fpsyt.2023.1167910

Abstract:

The pharmaceutical industry’s influence on psychiatric research and practice has been profound and has resulted in exaggerated claims of the effectiveness of psychotropic medications and an under-reporting of harms. After the regulatory approval of fluoxetine, the pharmaceutical industry began promoting (and continues to promote) a chemical imbalance theory of emotional distress. In the last decade, there has been an increased awareness about the limits of this theory and the risks of psychotropic medications. Nonetheless, the medicalization of distress, the sedimented belief in “magic bullets,” and the push to “scale up” mental health treatment have contributed to the meteoric rise in the prescription of psychiatric drugs and of polypharmacy. A major premise of this paper is that the conceptual framework of medical nihilism can help researchers and clinicians understand and address the harms incurred by inflated claims of the efficacy of psychotropic medications. We propose that psychiatry, and the mental health field more generally, adopt a model of ‘gentle medicine’ with regard to both the diagnosis of and treatment for mental health conditions and focus greater attention on the upstream causes of distress. Read more …


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New Treatments for Mental Disorders Should Routinely be Compared to Psychotherapy in Trials Conducted for Regulatory Purposes

Criste, I. Halvorsen, I. Cosgrove, L.  Naudet, F. (2022). Lancet Psychiatry, Volume 9, ISSUE 12, P934-936, December 2022, DOI:https://doi.org/10.1016/S2215-0366(22)00340-6

Abstract:

Treatments for mental disorders stem from various intervention classes, such as pharmacological, psychosocial, and physical. However, whereas drugs, biologics, and devices are formally regulated by public agencies, such as the US Food and Drug Administration or the European Medicines Agency, psychotherapies are largely unregulated. We are concerned that regulatory trials for the treatment of mental disorders exclude or do not evaluate psychotherapies, even when one is ostensibly a constituent of the combination therapy submitted for approval. In trials conducted for the regulatory approval of drug-assisted psychotherapies, such as 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder (PTSD) and psilocybin-assisted therapy for treatment-resistant depression, there were no specific requirements for or an evaluation of the psychotherapy component. In the MDMA trial, both the treatment and the comparator groups received a bespoke psychological intervention, not previously tested in independently conducted randomised trials, instead of one of several evidence-based alternatives. Read more …


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Harm Reduction, Humanistic Psychology, and the CRPD

D’Ambrozio, G., Cosgrove, L., Lilly, S., & McCarthy, T. (2022), Journal of Humanistic Psychology, 0(0). https://doi.org/10.1177/00221678221136240

Abstract:

Harm reduction, which was initially developed as a public health response to illicit drug use, has relevance to the prescription of psychotropic medication. Indeed, focusing on the agency of people who use drugs—licit or illicit— facilitates a more authentic engagement with treatment. In this paper, we show how the framework of harm reduction is congruent with the guiding principles of both humanistic psychology and the Convention on the Rights of Persons with Disabilities (CRPD). Moreover, applying a harm reduction model to psychotropic drug use raises awareness that there are risks to taking these medications, risks which are frequently glossed over because of the emphasis on medication adherence and compliance. We provide case examples of organizations that take a person-centered (vs. medication- centered) approach to people experiencing mental health crises. In their unique ways, these organizations embody the principles of harm reduction and the humanistic impulse that informs the CRPD. Read more …


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Industry Effects on Evidence: A case study of long-acting injectable antipsychotics. 

Cosgrove, L., Mintzes, B.,  D’Ambrozio, G., Bursztajn, J., Shaughnessy, A. S. (2022).
Accountability in Research.  10.1080/08989621.2022.2082289 

Abstract:

A vigorously debated issue in the psychiatric literature is whether long-acting injectable antipsychotics (LAIs) show clinical benefit over antipsychotics taken orally. In addressing this question, it is critical that systematic reviews incorporate risk of bias assessments of trial data in a robust way and are free of undue industry influence. In this paper, we present a case analysis in which we identify some of the design problems in a recent systematic review on LAIs vs oral formulations. This case illustrates how evidence syntheses that are shaped by commercial interests may undermine patient-centered models of recovery and care. We offer recommendations that address both the bioethical and research design issues that arise in the systematic review process when researchers have financial conflicts of interest. Read more …

Industry Effects on Evidence: A case study of long-acting injectable antipsychotics.  Read More »

Global health, human rights, and neoliberalism: The need for structural frameworks when addressing mental health disparitie

(2022)

Herrawi, F., Logan, J., Cheng, P., & Cosgrove, L. Journal of Theoretical and Philosophical Psychology, 52-60

Abstract:
This paper argues that the field of psychology—and the psy-disciplines generally—need to embrace an interdisciplinary approach if they are to be relevant and contribute to global social justice initiatives. It focuses on two such initiatives: The Global Mental Health movement and calls for increasing access to mental health services for immigrants. It suggests that a stronger focus on the upstream causes of ill-health, a deeper appreciation for the ways in which neoliberalism deflects attention away from these upstream determinants, and a greater engagement with the field of human rights and other disciplines will lead to more substantive gains in population mental health. Read more

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Where Clinical Practice Guidelines Go Wrong

Barry, H., Cosgrove, L. Slawson, D (2022), American Family Physician. PMID: 35426634.

Abstract:

Clinical practice guidelines, essential tools for evidence-based practice, have proliferated over the past few decades but remain controversial for several reasons, including discordance among guidelines, the influence of intellectual and financial conflicts of interest, and a lack of adherence to standards for developing trustworthy guidelines. In this editorial, we will use recent hypertension guidelines to illustrate guideline discordance and then propose how to identify trustworthy guidelines. Read more …


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Financial Conflicts of Interest in Psychopharmacology Textbooks

Cosgrove, L. Herrawi, F. Shaughnessy, A. (2021) Community Mental Health Journal. doi:10.1007/s10597-021-00906-6

Abstract:

While most medical journals require disclosures of industry payments to authors and editors, there is no requirement for textbooks. In this study we evaluated nine well-known psychopharmacology textbooks to identify payments to their writers and editors. Two-thirds of the textbooks had at least one editor or author who received personal payments from one or more pharmaceutical companies, for a total of 11,021,409 USD paid to 11 of 21 editors/authors over a seven-year period. Much of this money was paid to a single author but 24% of the writers received over 75,000 USD each over this time period. There are several psychopharmacology textbooks authored by writers without apparent financial conflicts of interest. Just as with medical journals, medical textbooks should be transparent about payments made to their authors and editors. Read more …

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Beware of equating increased access to mental health services with health equity: The need for clinical and epistemic humility in psychology

(2021)

Cosgrove, L., & Herrawi, F, The Humanistic Psychologist

Abstract:
As the coronavirus public health crisis continues to affect countries around the world, it has become increasingly evident that the burdens that are imposed by the pandemic are not shared equally. Those with fewer resources, immigrants, and members of marginalized and racialized groups are at a disproportionate risk of physical harm and emotional distress from coronavirus 2019. However, when responses to discrimination, social disadvantage, and racism are captured as depression, this may result in overmedicalization and overtreatment. Instead of focusing predominantly on increased access to mental health services, humanistic psychology has long recognized the need to address the structural and systemic obstacles that undermine well-being. Indeed, responses to wide-scale human suffering that focus exclusively on intraindividual interventions often keep the status quo intact and do not animate our political imagination. If mental health issues are embedded in inequality, which is a social and structural category, not a psychological category, then it is ignorance producing to suggest that one can solve mental health issues on an individual, psychological level. Finally, an important lesson can be learned from humanistic psychology’s emphasis on empathic dwelling when bearing witness to human suffering. Empathic dwelling is not a cognitive or intellectual exercise that simply facilitates mental health treatment. Rather, it is a purposeful stance or comportment from which we try “to feel one’s way into the other’s experience [ein-fu¨ hlen] . . . [what] Husserl described as ‘trading places’”. It is only in and through this type of comport ment, this deeply felt attunement, that we will be able to bring clinical and epistemic humility to fruition. Read more

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Digital aripiprazole as a human technology

(May 2021)

Cosgrove, L., Morrill, Z. & Karter J. Economy and Society, Vol 50, 2021 – Issue 3, p359

Abstract:
The Food and Drug Administration (FDA) recently approved the first ever ‘digital’ drug, an antipsychotic (aripiprazole) embedded with a sensor (Abilify MyCite) that tracks data about drug ingestion as well as activity level and mood patterns. In this paper, we identify the financial and sociopolitical drivers that have facilitated the development and regulatory approval of a digital drug marketed for people with psychotic disorders. We explore the novel ways that such devices blur the distinctions between medication, machine and mind. The risks of digital aripiprazole obscuring and exacerbating the effects of social inequity are discussed. However, we also consider the possibility that this digital psychotropic drug may allow for new forms of personhood, performances of subjectivity, and resistance to emerge. This paper addresses both the conditions that enabled the development of digital aripiprazole as well as the possibilities and limitations it may bring to health providers and service-users. Read more

Digital aripiprazole as a human technology Read More »

Digital Phenotyping and Digital Psychotropic Drugs: Mental Health Surveillance Tools That Threaten Human Rights

(Dec 2020)

Cosgrove, L., Karter, J.M., McGinley, M., Morrill, Z. Harvard Health and Human Rights 2020 Dec, 22(2): 33-39

Abstract:
Digital technologies and tools hold much promise. Indeed, the COVID-19 pandemic has shown us how helpful telehealth platforms and mental health applications (apps) can be in a time of quarantine and social distancing. However, such technologies also pose risks to human rights at both the individual and population levels. For example, there are concerns not just about privacy but also about the agency and autonomy of the person using mental health apps. In this paper, we describe what digital phenotyping is, how it is used to predict mood, and why we ought to exercise caution before embracing it as a means of mental health surveillance. We also discuss the United States’ recent regulatory approval of the first-ever “digital” drug, an antipsychotic (aripiprazole) embedded with a sensor. Digital aripiprazole was developed in order to increase medication compliance, but we argue that it may undermine a rights-based approach in the mental health field by reinforcing coercive practices and power imbalances. The global dissemination and promotion of these apps raise human rights concerns. Read more

Digital Phenotyping and Digital Psychotropic Drugs: Mental Health Surveillance Tools That Threaten Human Rights Read More »

The Cultural Politics of Mental Illness: Toward a Rights-Based Approach to Global Mental Health

(16 October 2020)

Cosgrove, L., Morrill, Z., Karter, J.M., Valdes, E., Cheng, C. Community Ment Health J 57, 3-9 (2021)

Abstract:
The movement for global mental health (MGMH) has raised awareness about the paucity of mental health services, particularly in low- and middle-income countries. In response, policies and programs have been developed by the World Health Organization and by the Lancet Commission on global mental health, among other organizations. These policy initiatives and programs, while recognizing the importance of being responsive to local needs and culture, are based on Western biomedical conceptualizations of emotional distress. In the paper, we discuss how a rights-based approach can promote the voice and participation of people with lived experience into the MGMH. We argue that a human rights framework can be enhanced by incorporating the conceptual approaches of critical inquiry and community mental health. We also discuss how rights-based approaches and service-user activism can productively reconfigure Western psychiatric conceptualizations of distress and provide both a moral and empirical justification for a paradigm shift within the MGMH. Read more

The Cultural Politics of Mental Illness: Toward a Rights-Based Approach to Global Mental Health Read More »

“Do Antidepressants Work?” A Humanistic Perspective on a Long-Standing and Contentious Debate

(2020)

Cosgrove, L., Troeger, R., & Karter, J. M. The Humanistic Psychologist, 48(3), 221-231

Abstract:
Since the approval of fluoxetine in 1987, there have been contentious debates about whether antidepressants “work.” A recent meta-analysis on the efficacy and tolerability of antidepressants reinvigorated debates about their effectiveness—debates that have important implications for both research and practice in humanistic psychology. This article briefly discusses the findings and identifies the limitations of this meta-analysis, and we show that using psychopharmacology as a routine first response is not evidence based and incongruent with the basic principles of humanistic psychology. Additionally, we argue that the question “do antidepressants work?” is reductive and undermines our responsibility to individuals who are suffering from emotional distress. Responding to the Cipriani et al. (2018) study from a humanistic lens (a) deepens our appreciation for the lived experience of individuals diagnosed with depression and our responsibility to them, (b) complicates assumptions about the ontological status of “depression,” and (c) enhances collaborative, client-centered decision-making. Read more

“Do Antidepressants Work?” A Humanistic Perspective on a Long-Standing and Contentious Debate Read More »

Mental Health as a Basic Human Right and the Interference of Commercialized Science

(June 2020)

Cosgrove, L. & Shaughnessy A, Harvard Health and Human Rights, Vol 22/1, June 2020, pp 61 -68

Abstract:
Although there is consensus that a rights-based approach to mental health is needed, there is disagreement about how best to conceptualize and execute it. The dominance of the medical model and industry’s influence on psychiatry has led to an over-emphasis on intra-individual solutions, namely increasing individuals’ access to biomedical treatments, with a resultant under-appreciation for the social and psychosocial determinants of health and the need for population-based health promotion. This paper argues that a robust rights-based approach to mental health is needed in order to overcome the effects of commercial interests on the mental health field. We show how commercialized science—the use of science primarily to meet industry needs—deflects attention away from the sociopolitical determinants of health, and we offer solutions for reform. Read more

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Drivers of and Solutions for the Over-Use of Antidepressant Medication in Pediatric Populations

Cosgrove, L. Morrill, Z., Yusif, M., Vaswani, A., Cathcart, S., Troeger, R., and Karter,
J.M. (2020) Front. Psychiatry, 13 February 2020, Sec. Child and Adolescent Psychiatry, Volume 11 – 2020

Abstract:

Children in the United States and internationally are increasingly being diagnosed with depression and related psychiatric conditions and a recent study found that antidepressant (ADM) use in children and adolescents rose substantially in youth cohorts in five Western countries from 2005 to 2012. However, there has been ongoing controversy over the effectiveness and safety of ADM use in children, including concerns about ADM increasing suicidality and self-harm. In addition to the increase in the diagnosis of depression, commercially driven off-label prescriptions have been cited as a significant reason for high rates of pediatric ADM prescribing. In this commentary, we discuss two drivers of the overuse of ADM, both of which are products of an increasingly medicalized approach to mental health: 1) the demand for mental health and depression screening in youth, despite the lack of evidence to support it, and 2) the renewed momentum of the Global Mental Health Movement and concomitant calls to “scale up” the diagnosis and treatment of mental illness. Using the lens of institutional corruption, we identify the ways in which both guild and financial conflicts of interest create obstacles to rational prescribing practices in pediatric populations and offer suggestions for reform. Read more …

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A critical review of the Lancet Commission on global mental health and sustainable development: Time for a paradigm change

Cosgrove, L., Mills, C., Karter, J. Mehta, A., Kalathil, J. (2019). A critical review of the Lancet Commission on global mental health and sustainable development: Time for a paradigm change. Critical Public Health. https://doi.org/10.1080/09581596.2019.1667488

Abstract:

In October 2018, the UK government, positioning itself as a global leader in mental health, hosted a Global Ministerial Mental Health Summit. The event was scheduled to coincide with the publication of the Lancet Commission on Global Mental Health and Sustainable Development. Despite claiming a public health and social determinants approach, the report focused on the importance of ‘closing the treatment gap’ through the use of Western diagnostic tools and interventions. In response, coalitions of mental health activists and service-users organised open letters detailing their concerns with the summit and report. Among these concerns were the ways in which recent UK government policies, particularly welfare reform, violated the rights of persons with disabilities; the lack of stakeholder representation and involvement in the report; and the continuation of the colonial legacy in which the ‘North drives the South.’ Expanding on the concerns raised by this coalition of activists and service-users, we argue that a focus on societal (structural) determinants and political economy could open new possibilities for global mental health beyond narrow individualized interventions. Additionally, we suggest that a politically informed societal determinants of health framework is needed in order to move the Global Mental Health Movement in a more emancipatory direction.

A critical review of the Lancet Commission on global mental health and sustainable development: Time for a paradigm change Read More »

Global Mental Health

Cosgrove, L., Mills, C, Amsterdam, J., Heath, I., Mehta, A., Kalathil, J., & Shaughnessy, A. The Lancet, 2019 Jul 13;394 (10193): 117-118.

To enhance the commitment of the Lancet Commission on global mental health and sustainable development set out by Vikram Patel and colleagues1—to reframe the global mental health agenda within the broader conceptualisation of mental health, envisioned in the Sustainable Development Goals—we offer some suggestions for further reform. Read more

Global Mental Health Read More »

Digital aripiprazole or digital evergreening? A systematic review of the evidence and its dissemination in the scientific literature and in the media

(2019)

Cosgrove, L., Cristea, I., Shaughnessy, A., Mintzes, B., Naudet, F. BMJ Evidence-Based Medicine 2019;24:231-238

Abstract:
Background In November 2017, the Food and Drug Administration (FDA) approved a version of a second-generation antipsychotic, aripiprazole, embedded with a sensor (Abilify MyCite).
Objective To systematically review the evidence supporting the FDA’s approval of digital aripiprazole and how that evidence was disseminated in the scientific literature and news reports. Read more

Digital aripiprazole or digital evergreening? A systematic review of the evidence and its dissemination in the scientific literature and in the media Read More »

Why a rights-based approach to global mental health is not “anti-psychiatry”

(March 2019)

Cosgrove, L. & Jureidini J. (2019). Australian and New Zealand Journal of Psychiatry, 53(6):000486741983345

Abstract:
In a recent ‘Debate’ article, Dharmawardene and Menkes (2018) criticize the 2017 Report of the Special Rapporteur on the ‘right of everyone to the enjoyment of the highest attainable standard of physical and mental health’ (UN Human Rights Council, 2017). While praising the Report for drawing attention ‘to the pernicious problem of human rights abuses of the mentally ill’, they conclude that it is imbalanced and ideologically biased against biomedical approaches (p. 1). To facilitate discussion and debate about how best to integrate a rights-based discourse into mental health policy and practice, we list their three main criticisms below and offer the following responses. Read more

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No magic pill: A prescription for enhancedshared decision-making in the treatment of depression

(Jan 2019)

Cosgrove, L. Erlich, D. Shaughnessy, A. Journal of the American Board of Family Medicine, 2019 Jan-Feb; 32(1): 6-9

Abstract:
For over 2 decades, there have been debates, sometimes contentious, about the efficacy and safety of antidepressants. Growing awareness of the difficulty some patients have when discontinuing these medications has intensified these debates. Recently, Cipriani and colleagues published the largest meta-analysis to date that assessed the efficacy and tolerability of antidepressants. They concluded that all were more efficacious than placebo, and they also synthesized the trial results from head-to-head studies in an effort to guide pharmacologic treatment for major depressive disorder in adults. Although the researchers acknowledged many limitations in their analysis, including the fact that effect sizes were modest at best, the media overstated the results of the study. Both the meta-analysis and the news stories reinvigorated the debates about whether or not antidepressants “work.” Unfortunately, however, the key question-how can this meta-analysis help physicians in assisting their patients with a difficult decision about depression treatment options?-was lost in the controversy. In this commentary, we identify the questions and challenges that were not addressed in the current debate and offer specific suggestions for enhancing shared decision making for physicians working in primary care settings. Read more

No magic pill: A prescription for enhancedshared decision-making in the treatment of depression Read More »