Ethics

Industry Influence on Mental Health Research: Depression as a Case Example

Cosgrove L, Patterson EH, Bursztajn HJ, Front Med (Lausanne). 2024 Jan 23;10:1320304 DOI: 10.3389/fmed.2023.1320304

Abstract:

Emotional distress has been rising since before the COVID-19 pandemic and the public is told that depression is a major public health problem. For example, in 2017 depressive disorders were ranked as the third leading cause of “years lost to disability” and the World Health Organization now ranks depression as the single largest contributor to global disability. Although critical appraisals of the epidemiological data raise questions about the accuracy of population-based depression estimates, the dominance of the medical model and the marketing of psychotropics as “magic bullets,” have contributed to a dramatic rise in the prescription of psychiatric drugs. Unfortunately, the pharmaceutical industry’s influence on psychiatric research and practice has resulted in over-estimates of the effectiveness of psychotropic medications and an under-reporting of harms. This is because the principles that govern commercial entities are incongruent with the principles that guide public health research and interventions. In order to conduct mental health research and develop interventions that are in the public’s best interest, we need non-reductionist epistemological and empirical approaches that incorporate a biopsychosocial perspective. Taking depression as a case example, we argue that the socio-political factors associated with emotional distress must be identified and addressed. We describe the harms of industry influence on mental health research and show how the emphasis on “scaling up” the diagnosis and treatment of depression is an insufficient response from a public health perspective. Solutions for reform are offered. Read more


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Conflicts of Interest Should be Prohibited Among the Diagnostic and Statistical Manual of Mental Disorders Panel and Task Force Members

L Cosgrove, BMJ 2024;384:q36

Abstract:
When the DSM-5 text revision was published in 2022, we identified the amount and type of payments received by DSM panel members—a task made possible by the development of the Open Payments database. We hoped that there would be a decrease in financial conflicts of interest. As with DSM-IV and DSM-5, however, conflicts of interest among the panel members for the DSM-5 text revision were prevalent. Of the 92 panel members who met inclusion criteria, 55 (60%) received payments from industry. Collectively, these panel members received $14.2m. Read more

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Undisclosed Financial Conflicts of Interest in DSM-5-TR: cross sectional analysis

Davis L C, Diianni A T, Drumheller S R, Elansary N N, DAmbrozio G N, Herrawi F, Piper,J, Cosgrove, L
BMJ 2024; 384 :e076902 doi:10.1136/bmj-2023-076902

Abstract:

Conflicts of interest among panel members of DSM-5-TR were prevalent. Because of the enormous influence of diagnostic and treatment guidelines, the standards for participation on a guideline development panel should be high. A rebuttable presumption should exist for the Diagnostic and Statistical Manual of Mental Disorders to prohibit conflicts of interest among its panel and task force members. When no independent individuals with the requisite expertise are available, individuals with associations to industry could consult to the panels, but they should not have decision making authority on revisions or the inclusion of new disorders. Read more …


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Becoming a Phronimos: Evidence-Based Medicine, Clinical Decision Making, and the Role of Practical Wisdom in Primary Care

Cosgrove, L. & Shaughnessy, A. (2023), Journal of the American Board of Family Medicine. doi: 10.3122/jabfm.2023.230034R1

Abstract:

There has been much discussion about the overmedicalization of human experience and the problems incurred by overzealous action-oriented medical care. In this paper we describe the Aristotelean virtue of phronesis, or practical wisdom, and discuss how it can be developed by interested clinicians. We argue that becoming a phronimos requires conscious attention to one’s practice by using feedback to continually improve. But there must also be judicious adherence to clinical practice guidelines and advocacy for people-as-patients at individual, community, and national levels. Read more …


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Financial Conflicts of Interest in Psychopharmacology Textbooks

Cosgrove, L. Herrawi, F. Shaughnessy, A. (2021) Community Mental Health Journal. doi:10.1007/s10597-021-00906-6

Abstract:

While most medical journals require disclosures of industry payments to authors and editors, there is no requirement for textbooks. In this study we evaluated nine well-known psychopharmacology textbooks to identify payments to their writers and editors. Two-thirds of the textbooks had at least one editor or author who received personal payments from one or more pharmaceutical companies, for a total of 11,021,409 USD paid to 11 of 21 editors/authors over a seven-year period. Much of this money was paid to a single author but 24% of the writers received over 75,000 USD each over this time period. There are several psychopharmacology textbooks authored by writers without apparent financial conflicts of interest. Just as with medical journals, medical textbooks should be transparent about payments made to their authors and editors. Read more …

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